Peculiarities of the induction immunosuppressive therapy in renal transplantation

[Immunosuppressive therapy in renal transplantation].

In 1960, the beneficial effect on allograft survival of 6-mercaptopurine (6-MP) was demonstrated. In 1961, azathioprine, a less toxic derivative of 6-MP, was synthesized and soon became the main form of maintenance therapy. Around the same time, clinical studies of the effects of corticosteroids on the immune system were being conducted and successful reversal of rejection with cortisone was re...

Immunosuppressive therapy and breast-feeding after renal transplantation.

Immunosuppressive Therapy After Cardiac Transplantation

In contrast to renal or pancreas transplantation graft failure after heart transplantation (HTx) is associated with the death of the patient if re-grafting or mechanical support (MCS) is not possible immediately. Since the beginning of modern transplantation medicine one of the highest priorities were preventing and treating graft rejection. Over the last decades experimental, animal and clinic...

Clinical experience with induction therapy in renal transplantation

INTRODUCTION Acute rejection (AR) is a major determinant of renal allograft survival. The incorporation of new immunosuppressive agents explains the improvement seen in the results of transplantation in recent years. OBJECTIVE To assess the optimal immunosuppression regimen according to the immunological risk of renal transplant patients. METHOD We performed a retrospective study of 977 con...

Modern Immunosuppressive Therapy in Kidney Transplantation

Immunosuppressive therapy is a key component for successful kidney transplantation. It is commonly believed that more intensive immunosuppression is needed initially to prevent rejection episodes and less immunosuppression is subsequently maintained to minimize the overall risk of infection and malignancy. The selection of drugs should be guided by a comprehensive assessment of the immunologic ...